Not for human consumption

GHRP-6 Peptide: The Founding GH Secretagogue Hexapeptide | Research Grade

GHRP-6 research peptide: ≥99% HPLC-verified purity, manufactured in LiveWell’s own Dallas cGMP facility. GHRP-6 (growth hormone-releasing hexapeptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) is the founding compound of the GHRP family: the unnatural peptide from the Bowers laboratory whose distinct, GHRH-independent action led to the cloning of GHS-R1a and the discovery of ghrelin. Supplied as a 10 mg lyophilized vial for in-vitro laboratory research use only.

Coming soon: pre-orders are open now. The first production batch is in the manufacturing and QC queue. Expected ship date: to be announced. Pre-orders ship in the order received once the batch clears third-party testing and the COA is published. Your card is charged at checkout and you can cancel any time before shipment for a full refund.

CAS Number: 87616-84-0 · Also known as: growth hormone-releasing hexapeptide, SKF-110167
Vial size: 10 mg lyophilized powder
Class: Growth hormone secretagogue (founding GHRP), GHS-R1a agonist
Purity: ≥99% HPLC, third-party tested, COA published on release
Shipping: USA same-day once released (orders before 2pm CT, Mon to Fri) · free over $200

Related: Ipamorelin · Sermorelin · CJC-1295 + Ipamorelin

For laboratory research use only. Not for human or animal consumption. Full details ↓

$ 34.99

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⚠️ Strictly for laboratory research use only. Not for human or animal consumption.

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6-9	$ 29.74	15%
10+	$ 27.99	20%

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Description

GHRP-6: The Founding GH Secretagogue for Research Use

GHRP-6 (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) is a synthetic six-amino-acid peptide with a singular place in endocrinology: it is the compound that revealed a second GH-releasing system in the body. Developed in the Bowers laboratory from enkephalin analogs, GHRP-6 released growth hormone through a mechanism that was clearly not GHRH, a puzzle that drove the 1996 cloning of the orphan receptor GHS-R1a and the 1999 isolation of its natural ligand, ghrelin. Beyond GH release, GHRP-6 is a standard tool in appetite-circuit research, and its antagonist derivative [D-Lys3]-GHRP-6 is the most widely used GHS-R blocker in the literature. LiveWell supplies it as a 10 mg lyophilized vial strictly for in-vitro laboratory research use only.

Chemical Information

Name: GHRP-6 (growth hormone-releasing hexapeptide, SKF-110167)
CAS Number: 87616-84-0
Type: Synthetic hexapeptide GH secretagogue (research grade)
Sequence: His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Molecular weight: approximately 873 g/mol
Mechanism: GHS-R1a agonist at hypothalamus and pituitary, synergistic with GHRH; orexigenic via arcuate and paraventricular NPY circuits
Vial size: 10 mg lyophilized powder
Purity: ≥99% (HPLC, third-party tested)

Why Researchers Study GHRP-6

1. Historic reference compound. The path from GHRP-6 to the ghrelin receptor is one of reverse pharmacology’s textbook stories, documented in the Bowers Methods in Enzymology history. Any laboratory studying GHS-R1a starts here.

2. The antagonist scaffold. [D-Lys3]-GHRP-6 is the standard competitive GHS-R antagonist across hundreds of papers, including renal and blood-pressure studies, so the parent peptide anchors an entire tool-compound family.

3. Appetite circuit research. GHRP-6 induces c-fos expression in arcuate and paraventricular feeding nuclei with food intake peaking around 3 hours after dosing in rodents, a clean model for ghrelin-pathway orexigenic signaling.

4. Comparative secretagogue panel. GHRP-6 with GHRP-2 and Hexarelin forms the classic hexapeptide potency series used to benchmark newer agonists such as Ipamorelin.

Published Clinical Literature (Research Reference)

For context only. These are findings from the foundational secretagogue literature and academic laboratories. These are results cited from peer-reviewed sources; they are not claims about LiveWell’s research-grade material.

Dose-response characterization, rat (Endocrinology, 1985): the original in-vivo potency series for GH-releasing peptides in the unanesthetized rat.
Acromegaly series (J Clin Endocrinol Metab, 1993): the GH response to GHRP-6 did not correlate with the GHRH response but correlated tightly with TRH (r = 0.95), evidence for a distinct receptor mechanism.
GHRP review (Cell Mol Life Sci, 1998): Bowers summarizes two decades of GHRP pharmacology before ghrelin was found.
History of ghrelin discovery (Methods Enzymol, 2012): the first-person account of how GHRP-6 led to GHS-R1a and ghrelin.
Feeding circuits (Sheng Li Xue Bao, 2016): GHRP-6 induced c-fos in arcuate and paraventricular nuclei peaking at 1 hour, with food intake peaking at 3 hours.
Regulatory: never approved anywhere; research use only; prohibited in sport by WADA.

Storage & Handling

Store lyophilized vials refrigerated at 2 to 8°C, protected from light and heat
Reconstitute with bacteriostatic water; reconstituted material has a shorter storage window
Follow your laboratory’s standard peptide handling protocol

⚠️ Disclaimer: GHRP-6 research peptide is intended strictly for laboratory research and in-vitro use only. It is not a drug, food, cosmetic, or dietary supplement. This product has not been evaluated or approved by the FDA and is not for human or veterinary use. No therapeutic, weight-management or metabolic-health claims are made or implied.

Regulatory status: GHRP-6 is a research compound that has never been approved in any country and is listed on the WADA prohibited list. The research-grade material sold by LiveWell is not a drug product: it is not manufactured, compounded, or approved for pharmaceutical use, and is strictly for in-vitro laboratory research. Nothing on this page constitutes medical advice.

GHRP-6 research reference: View the ghrelin discovery history on PubMed

Pre-Order GHRP-6 Research Peptide: cGMP Manufactured in Dallas, TX

Qualified researchers can pre-order GHRP-6 directly from the manufacturer. LiveWell Peptides produces research-grade GHRP-6 in our cGMP facility in Dallas, Texas. Every vial is third-party tested to verify ≥99% HPLC purity, amino acid identity by mass spectrometry, and endotoxin limits by LAL testing, and the batch COA is published on our COA page on the day of release. Pre-orders ship in the order received (expected ship date: to be announced); once released, US orders placed before 2pm CT (Mon to Fri) ship same-day in cold-chain packaging, with free domestic shipping over $200. International shipping is available.

Why Researchers Source GHRP-6 from LiveWell

Documentation, not claims. Every batch ships with a verified COA confirming identity and purity, published on our COA page rather than supplied only on request.

Four-point analytical testing. HPLC for purity, mass spectrometry for amino acid identity, and LAL testing for endotoxins, with independent third-party verification on top of in-house quality control.

US manufacturing and cold-chain logistics. Orders ship from our Dallas, Texas facility, with international shipping to Colombia, Mexico, Brazil, Argentina, Chile and Peru.

Related research compounds

Hexarelin (GHS-R1a + CD36) · GHRP-2 (pralmorelin) · Ipamorelin (selective GHS-R agonist) · Sermorelin (GHRH 1-29) · Bacteriostatic Water · Certificates of Analysis

Research literature

Selected peer-reviewed sources for research reference:

McCormick GF et al. (1985). Dose-response characteristics of various peptides with growth hormone-releasing activity in the unanesthetized male rat. Endocrinology. PMID: 2861083
Alster DK et al. (1993). The growth hormone (GH) response to GH-releasing peptide, GH-releasing hormone, and thyrotropin-releasing hormone in acromegaly. J Clin Endocrinol Metab. PMID: 8370708
Bowers CY. (1998). Growth hormone-releasing peptide (GHRP). Cell Mol Life Sci. PMID: 9893708
Bowers CY. (2012). History to the discovery of ghrelin. Methods Enzymol. PMID: 22975043
Kemp BA et al. (2014). Intrarenal ghrelin receptor antagonism prevents high-fat diet-induced hypertension in male rats. Endocrinology. PMID: 24797629

References are provided for research reference only. Inclusion of literature does not constitute a recommendation, endorsement, or claim for any specific use of LiveWell Peptides products. Products are sold for laboratory and research use only and are not intended for human consumption, injection, topical application, or any other administration to the human body.

Frequently Asked Questions

What is GHRP-6?

GHRP-6 (CAS 87616-84-0) is the founding synthetic hexapeptide of the GHRP family, an agonist of the ghrelin receptor GHS-R1a whose pharmacology led to the discovery of ghrelin itself. We supply it as a 10 mg lyophilized vial strictly for in-vitro laboratory research.

Why is GHRP-6 historically important?

Its GH-releasing action could not be explained by GHRH, which pushed the field to clone the orphan receptor GHS-R1a in 1996 and isolate ghrelin in 1999. The compound predates and predicted an entire hormone system.

How does GHRP-6 differ from GHRP-2 and Hexarelin?

All three are GHS-R1a hexapeptides. GHRP-6 is the original; GHRP-2 reached diagnostic approval in Japan; Hexarelin is the most potent GH releaser and adds CD36 binding. In published potency comparisons GHRP-6 sits below both.

What is [D-Lys3]-GHRP-6?

A single-substitution derivative of GHRP-6 that blocks rather than activates GHS-R1a. It is the standard ghrelin-receptor antagonist across the research literature, which keeps the parent scaffold central to receptor pharmacology.

Why is GHRP-6 used in appetite research?

Published rodent work shows GHRP-6 activates arcuate and paraventricular feeding nuclei, with food intake peaking around 3 hours after dosing, making it a clean ghrelin-pathway orexigenic probe. Cited for research reference only.

What purity is LiveWell GHRP-6, and is a COA included?

Every batch is third-party tested at ≥99% purity by HPLC, with mass spectrometry identity confirmation and LAL endotoxin testing. The batch Certificate of Analysis is published on our COA page the day the pre-order batch is released.

How should GHRP-6 be stored and reconstituted?

Store the lyophilized vial refrigerated at 2 to 8°C, protected from light and heat. Reconstitute with bacteriostatic water; reconstituted material has a considerably shorter storage window.

How do pre-orders work, and when will it ship?

Pre-orders are charged at checkout and ship in the order received once the first batch clears third-party testing and the COA is published. You will receive tracking the day it ships. If you change your mind before shipment, contact us for a full refund.

Is GHRP-6 a drug or supplement?

No. GHRP-6 has never been approved by the FDA or any regulator. The research-grade material sold by LiveWell is not a drug product, dietary supplement, food or cosmetic, and it is not intended for human or animal consumption.

Péptidos de investigación disponibles con envío internacional. GHRP-6 de grado de investigación fabricado en instalaciones cGMP en Dallas, Texas. Certificado de análisis incluido con cada lote. Solo para uso en investigación.

Research Use Only Disclaimer: This product is sold strictly for in vitro laboratory research. NOT for human or animal consumption. LiveWell Peptides makes no medical claims.