MOTS‑C Research Peptide – (Laboratory Use Only)

MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S ribosomal RNA gene — one of only a small number of known mitochondrial-derived peptides (MDPs), first described in 2015. LiveWell supplies it as a synthetic research-grade compound strictly for laboratory and in-vitro scientific research. It is not approved for human or veterinary use.

What makes it unusual

Most peptides are encoded in nuclear DNA. MOTS-c is encoded in the mitochondrial genome itself, which is why it is studied as part of a distinct signalling class — mitochondrial-derived peptides — rather than alongside conventional nuclear-encoded peptides.

Chemical information

• Name: MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c)
• Sequence: MRWQEMGYIFYPRKLR
• Sequence length: 16 amino acids
• Source: Mitochondrial 12S rRNA-encoded
• Class: Mitochondrial-derived peptide (MDP)
• First described: 2015
• Available sizes: 10 MG, 20 MG, 40 MG
• Format: Lyophilized powder

Studied in

• Mitochondrial signalling research
• AMPK-pathway and folate-cycle studies
• Cellular energy-metabolism research
• Comparative research across the mitochondrial-derived peptide family

Storage & handling

• Store lyophilized vials refrigerated at 2–8°C, protected from light and heat
• Reconstitute with bacteriostatic water; reconstituted material has a shorter storage window
• Follow your laboratory’s standard handling and disposal protocol

⚠️ Disclaimer: MOTS-c is intended solely for laboratory research and in-vitro use. It is not a drug, food, cosmetic, or dietary supplement, has not been evaluated or approved by the FDA, and is not for human or animal use. It is not intended to diagnose, treat, cure or prevent any disease, and no therapeutic, metabolic-health, performance or anti-aging claims are made or implied.

Buy MOTS-c Research Peptide — cGMP Manufactured in Dallas, TX

LiveWell Peptides supplies research-grade MOTS-c manufactured in our cGMP facility in Dallas, Texas. Every vial is third-party tested by independent laboratories to verify ≥99% HPLC purity, amino acid identity by mass spectrometry, and endotoxin limits by LAL testing, with a batch-specific COA published on our COA page.

Available in 10 MG, 20 MG and 40 MG vials as lyophilized powder for reconstitution. US orders before 2pm CT (Mon–Fri) ship same-day in cold-chain packaging, with free domestic shipping over $200. International shipping is available. Sold strictly for research use only — not for human consumption.

Why Researchers Source MOTS-c from LiveWell Peptides

LiveWell Peptides is a US-based cGMP peptide manufacturer headquartered in Dallas, Texas, supplying research-grade peptides to laboratories, universities and qualified independent researchers.

Documentation, not claims. Every batch ships with a verified certificate of analysis (COA) confirming identity and purity, published on our COA page rather than supplied only on request.

Four-point analytical testing. Each lot is analysed by HPLC for purity, mass spectrometry for amino acid identity, and LAL testing for endotoxins, with independent third-party verification.

Related compounds in mitochondrial research. LiveWell also supplies NAD+, 5-Amino-1MQ and SS-31, all used in cellular energy and mitochondrial pathway research, allowing comparative work across related mechanisms from a single documented source.

US manufacturing and cold-chain logistics. Orders ship same-day from our Dallas, Texas facility in thermo-insulated packaging, with international shipping to Colombia, Mexico, Brazil, Argentina, Chile and Peru.

Related research compounds

NAD+ · 5-Amino-1MQ (NNMT inhibitor) · SS-31 (Elamipretide) · Glutathione · Bacteriostatic Water · All peptide vials · Certificates of Analysis

Research literature

MOTS-c has been the subject of 232 peer-reviewed publications indexed in PubMed. Selected recent literature for research reference:

• Liu S et al. (2026). Mitochondrial-derived peptide MOTS-c targets SLC7A11 to preserve spermatogenesis by suppressing ferroptosis. Free Radic Biol Med. PMID: 41933740
• Feng Z et al. (2026). MOTS-c and mitophagy pathway activation following altitude exposure in animal models. Free Radic Biol Med. PMID: 41654147

References are provided for research reference only. Inclusion of literature does not constitute a recommendation, endorsement, or claim for any specific use of LiveWell Peptides products. Products are sold for laboratory and research use only and are not intended for human consumption, injection, topical application, or any other administration to the human body.

Frequently Asked Questions