5-Amino-1MQ — NNMT Inhibitor | Research Grade

For Research Use Only – Not for Human or Animal Consumption

5-Amino-1MQ is a small-molecule compound known to inhibit nicotinamide N-methyltransferase (NNMT). Preclinical studies suggest its potential to support various metabolic and cellular pathways relevant to energy regulation, fat metabolism, and NAD⁺ optimization.

Fat Metabolism & Weight Reduction

May promote fat breakdown by inhibiting NNMT activity. In animal models, 5-Amino-1MQ has been associated with reduced fat mass and overall body weight without changes in caloric intake.

Metabolic Health Support

Shown to elevate NAD⁺ levels, which may enhance insulin sensitivity and glucose regulation via SIRT1 and GLUT4 pathways.

Muscle Preservation & Recovery

Preclinical data suggest improved muscle regeneration and satellite cell activity, indicating potential in muscle repair research.

Cellular Aging & NAD⁺ Restoration

By increasing NAD⁺, studies have observed improved mitochondrial function and a decrease in senescent cell activity.

Cardiovascular Research

May help lower plasma cholesterol and support anti-inflammatory responses through lipid regulation mechanisms.

Mitochondrial Function & Energy Output

Associated with increased mitochondrial efficiency and ATP production in laboratory settings.

Inflammation Modulation

Potential reduction of pro-inflammatory markers, suggesting relevance in inflammation and aging-related studies.

Oncology Research

NNMT inhibition has shown promise in slowing cancer cell proliferation and enhancing chemotherapy sensitivity in select cell lines (e.g., HeLa), though this is still under investigation.

Neuroprotective Potential

Emerging studies indicate possible benefits for brain NAD⁺ metabolism, with implications for cognitive and neurodegenerative research.