Semax Nootropic Peptide — ACTH(4-10) Analog | Research Grade
Semax (MEHFPGP) is a synthetic heptapeptide analog of ACTH(4-10), stabilised with a Pro-Gly-Pro extension. Studied in BDNF/trkB signalling and neurotrophic research. Supplied as a lyophilized vial in 5 MG and 10 MG sizes, for in-vitro laboratory research use only.
Research-grade specs
- CAS Number: 80714-61-0
- Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)
- Molecular formula: C37H51N9O10S
- Molecular weight: ~813.9 g/mol
- Class: ACTH(4-10) analog / melanocortin-derived peptide
- Available sizes: 5 MG, 10 MG
Studied applications
- BDNF and trkB expression research
- Neurotrophic signalling studies
- Comparative ACTH-analog structure-activity research
- Dopaminergic and serotonergic pathway studies in rodent models
Quality & trust
- ≥99% HPLC purity, third-party tested
- Mass spectrometry identity confirmation
- LAL endotoxin testing on every batch
- Batch-specific Certificate of Analysis included
- cGMP manufactured in Dallas, Texas (USA)
- USA same-day shipping (orders before 2pm CT M-F)
- Free domestic shipping on orders over $200
Storage & handling
- Store lyophilized vials refrigerated at 2–8°C short-term, or −20°C long-term
- Reconstitute with bacteriostatic water; reconstituted material has a shorter storage window
- Follow your laboratory’s standard peptide handling protocol
Related research: Selank · Epithalon · NAD+ · All peptide vials · Certificates of Analysis
Bulk & Wholesale Pricing
Frequently Asked Questions
Do I need a coupon code for bulk discounts?
No. Discounts apply automatically — just add the quantity to your cart and the bulk price updates at checkout.
What are the bulk discount tiers?
10% off for 3–5 units, 15% off for 6–8 units, and 20% off for 10 or more units.
Can I combine this with other discount codes?
No. Bulk discounts cannot be combined with other discount codes or coupons.
How do I order larger or wholesale quantities?
For volume or wholesale pricing, click Contact Sales or email sales@livewellpeptides.com with any further questions.
Thank you, Team LiveWell.
Research literature
Semax has been the subject of peer-reviewed publications indexed in PubMed. Selected recent literature for research reference:
- Kolbaev SN et al. (2025). The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain Neurons. Bull Exp Biol Med. PMID: 41171324
- Filippenkov IB et al. (2025). Genes That Associated with Action of ACTH-like Peptides with Neuroprotective Potential in Rat Brain Regions with Different Degrees of Ischemic Damage. Int J Mol Sci. PMID: 40650034
- Inozemtseva LS et al. (2024). Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress. Eur J Pharmacol. PMID: 39442746
- Filippenkov IB et al. (2024). Changes of Transcriptomic Activity in Rat Brain Cells under the Influence of Synthetic Adrenocorticotropic Hormone-Like Peptides. Biochemistry (Mosc). PMID: 39418522
- Sciacca MFM et al. (2022). Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models. ACS Chem Neurosci. PMID: 35080861
References are provided for research reference only. Inclusion of literature does not constitute a recommendation, endorsement, or claim for any specific use of LiveWell Peptides products. Products are sold for laboratory and research use only and are not intended for human consumption, injection, topical application, or any other administration to the human body.
Price range: $ 39.99 through $ 59.99
| Quantity | Price | Discount |
|---|---|---|
| 3-5 | $ 35.99 | 10% |
| 6-9 | $ 33.99 | 15% |
| 10+ | $ 31.99 | 20% |
Description
Semax (MEHFPGP) is a synthetic heptapeptide analog of the ACTH(4-10) fragment, stabilised by a Pro-Gly-Pro extension at the C-terminus. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in the 1980s, it is studied internationally as a nootropic research peptide. LiveWell supplies it as a lyophilized vial in 5 MG and 10 MG sizes, strictly for in-vitro laboratory research use.
Structure: The Pro-Gly-Pro extension is what distinguishes Semax from the native ACTH(4-10) fragment — the addition markedly increases enzymatic stability, which is the property most often examined in comparative peptide-stability research.
Studied in: BDNF and trkB expression research, neurotrophic signalling studies, comparative ACTH-analog structure-activity research, and dopaminergic and serotonergic pathway studies in rodent models. Published rodent work reports approximately a threefold increase in BDNF mRNA and a twofold increase in trkB mRNA in hippocampal tissue.
Chemical information
- Name: Semax (ACTH(4-10) Pro-Gly-Pro)
- CAS Number: 80714-61-0
- Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)
- Molecular formula: C37H51N9O10S
- Molecular weight: approximately 813.9 g/mol
- Length: 7 amino acids (heptapeptide)
- Class: ACTH(4-10) analog / melanocortin-derived peptide
- Available sizes: 5 MG, 10 MG
- Physical form: Lyophilized powder
Regulatory context
Semax has been registered as a pharmaceutical product in Russia since 2011, available there by prescription only. It holds no approval in the United States or European Union. The material supplied by LiveWell is a research chemical and is not a medicine — it is not for human or veterinary use in any jurisdiction.
Storage & handling
- Store lyophilized vials refrigerated at 2–8°C for short-term storage, or −20°C for long-term storage
- Protect from light and moisture
- Reconstitute with bacteriostatic water; reconstituted material has a shorter storage window and should be refrigerated
- Follow your laboratory’s standard peptide handling and disposal protocol
Semax research reference: View study on PubMed
Buy Semax Research Peptide — cGMP Manufactured in Dallas, TX
LiveWell Peptides supplies research-grade Semax manufactured in our cGMP facility in Dallas, Texas. Every vial is third-party tested by independent laboratories to verify ≥99% HPLC purity, amino acid identity by mass spectrometry, and endotoxin limits by LAL testing, and ships with a batch-specific certificate of analysis published on our COA page.
Available in 5 MG and 10 MG lyophilized vials. US orders placed before 2pm CT (Mon–Fri) ship same-day in cold-chain packaging, with free domestic shipping on orders over $200. International shipping is available. Sold strictly for research use only — not for human consumption.
Related research: Selank · Epithalon · NAD+ · Bacteriostatic Water · All peptide vials · Certificates of Analysis
Comprar Semax péptidos de investigación — análogo de ACTH(4-10) fabricado bajo estándares cGMP en Dallas, Texas. Certificado de análisis incluido. Envío internacional. Solo para uso en investigación de laboratorio.
Research Use Only Disclaimer: This product is sold strictly for in vitro laboratory research. NOT for human or animal consumption. LiveWell Peptides makes no medical claims.
Why Researchers Source Semax from LiveWell Peptides
LiveWell Peptides is a US-based cGMP peptide manufacturer headquartered in Dallas, Texas, supplying research-grade peptides to laboratories, universities and qualified independent researchers across the United States and internationally.
Documentation, not claims
Every batch of Semax ships with a verified certificate of analysis (COA) confirming identity and purity, published on our COA page rather than supplied only on request. Purity should be documented, not asserted.
Four-point analytical testing
Each lot is analysed by HPLC for purity, mass spectrometry for amino acid identity, and LAL testing for endotoxins, with independent third-party verification on top of in-house quality control.
Comparative nootropic-peptide research
LiveWell also supplies Selank, a synthetic analog of tuftsin studied in a related research area. Sourcing both from the same manufacturer allows structure-activity comparisons without introducing supplier variability into the study design.
US manufacturing and cold-chain logistics
Peptide stability depends on temperature control. Orders ship same-day from our Dallas, Texas facility in thermo-insulated packaging, with free domestic shipping over $200 and international shipping to Colombia, Mexico, Brazil, Argentina, Chile and Peru.
Bulk pricing and private label
Volume pricing applies automatically at checkout — 10% off at 3–5 units, 15% at 6–8, and 20% at 10 or more. For wholesale quantities or private label enquiries, contact our sales team.
Disclaimer: This product is sold strictly for laboratory and research use only. Not for human consumption. No medical claims are made or implied. Researchers are responsible for compliance with all applicable local, state, and federal regulations.
Péptidos de Investigación — LiveWell Peptides
LiveWell Peptides es un proveedor de péptidos en Estados Unidos de confianza para comprar péptidos de investigación de alta calidad. Cada lote de Semax incluye péptidos con certificado de análisis que documenta pureza e identidad verificadas, con péptidos cGMP fabricados en EE. UU.
Disponible para comprar Semax online con envío internacional de péptidos a toda Latinoamérica, incluyendo Colombia, México, Argentina, Chile, Perú y Brasil — para péptidos para investigación científica en universidades y laboratorios.
Aviso: Este producto se vende exclusivamente para uso en investigación y laboratorio. No apto para consumo humano.
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